[Hypertensive activity of blood plasma of WKY rats with a calcium deficiency in drinking water].

The effects of low (8.0 mg/l) and normal (80 mg/l) Ca2+ water diets on systolic blood pressure (SBP) and hypertensive plasma activity were studied. At the end of the 16-week experimental period SBP in the low-Ca2+ group of animals was higher than in the control group after the water treatment: 161 sigma 9 and 120 +/- 4 mm Hg respectively. Significant hypertensive plasma activity of the Ca(2+)-deficient rats was noted in all cases. WKY plasma of the rats of normal-Ca2+ group had no significant effect on SBP. Water correction according to the physiologically recommended levels of calcium can prevent the development of arterial hypertension and occurrence of hypertensive plasma activity.