Simbirtsev A S, Kotov A Iu, Pigareva N V, Vorontsov V I, Goncharov N P, Ketlinskiĭ S A
Biull Eksp Biol Med. 1993 Feb;115(2):183-5.
IL-1 and hydrocortisone have an opposite and competitive effect on the lymphocyte proliferation in cell culture. In mice recombinant human IL-1 beta dose-dependently induces high level serum corticosterone. Injection of IL-1 beta or hydrocortisone led to a similar alterations in the thymus: reduction of cellularity and decrease in spontaneous thymocyte proliferation. On the other hand in the same doses IL-1 beta stimulates spleen cell proliferation. IL-2 production and enhances serum antibody titres and the number of antibody producing cells in spleen of mice immunized with T-dependent antigen.
白细胞介素-1（IL-1）和氢化可的松在细胞培养中对淋巴细胞增殖具有相反的竞争性作用。在小鼠中，重组人IL-1β可剂量依赖性地诱导高水平血清皮质酮。注射IL-1β或氢化可的松会导致胸腺出现类似变化：细胞数量减少以及自发性胸腺细胞增殖降低。另一方面，相同剂量的IL-1β可刺激脾细胞增殖、白细胞介素-2（IL-2）产生，并提高用T细胞依赖性抗原免疫的小鼠的血清抗体滴度以及脾脏中抗体产生细胞的数量。
