[前列腺素E型在肿瘤细胞体外与自然杀伤细胞接触过程中的作用]
[The role of prostaglandins type E in tumor cells during their contact with NK-cells in vitro].
作者信息
Matveeva V A, Kliuchareva T E, Uvarova E N
出版信息
Biull Eksp Biol Med. 1993 Feb;115(2):193-4.
Active PGE--secretion by malignant tumour cells of Syrian hamsters was demonstrated 30 min after their contact with NK-cells in vitro. The duration of PGE--secretion depended upon the ratio of tumour cells and NK--cells, engaged in contact. Increase of the number of NK--cells (bound to tumour cells) up to 10:1-20:1 led to rapid release of PGE from majority of tumour cells; in this case PGE release was continued not longer than 1.5-2.0 hours. The active release of PGE can be stopped after the contact of tumour and NK--cells by indomethacin at any moment of its secretion.
叙利亚仓鼠恶性肿瘤细胞与自然杀伤细胞（NK细胞）在体外接触30分钟后，即表现出前列腺素E2（PGE₂）的活性分泌。PGE₂分泌的持续时间取决于参与接触的肿瘤细胞与NK细胞的比例。将（与肿瘤细胞结合的）NK细胞数量增加至10:1 - 20:1会导致大多数肿瘤细胞迅速释放PGE₂；在这种情况下，PGE₂的释放持续时间不超过1.5 - 2.0小时。在肿瘤细胞与NK细胞接触后，在PGE₂分泌的任何时刻，通过吲哚美辛均可停止其活性释放。
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