Rakhmanova I V, Iarygin V N, D'iakonova I N, Dreval' A A
Biull Eksp Biol Med. 1993 May;115(5):550-2.
Morphofunctional disorders in spiral ganglion in animals of different groups of age with neurosensory hardness of hearing due to ototoxic antibiotics have been shown. Antibiotic intoxication in kittens in early postnatal period arouses essential deviation from normal process of development of neurocytes in spiral ganglion. In the first rate low level of their metabolic activity must be shown. Delay of differentiation of neurocytes makes essential influence on the development of spiral ganglion as the unit of transmission of audio-information. The main feature of morphofunctional disorders in neurocytes of ganglion of grown-up animals is inhibition of protein synthesis mechanism activity.
已表明，由于耳毒性抗生素导致神经感觉性听力减退的不同年龄组动物，其螺旋神经节存在形态功能障碍。出生后早期小猫的抗生素中毒会引起螺旋神经节中神经细胞正常发育过程的本质偏离。首先，必须表现出它们代谢活动的低水平。神经细胞分化延迟对作为音频信息传递单元的螺旋神经节的发育产生重要影响。成年动物神经节神经细胞形态功能障碍的主要特征是蛋白质合成机制活性受到抑制。
