Bambagiotti-Alberti M, Coran S, Giannellini V, Favretto D, Traldi P
Dipartimento di Scienze Farmaceutiche dell'Università, Firenze, Italy.
Rapid Commun Mass Spectrom. 1994 Jun;8(6):439-42. doi: 10.1002/rcm.1290080602.
Positive- and negative-ion fast-atom bombardment (FAB) mass spectrometry has been employed to characterize pure dodecyl-, tetradecyl- and hexadecyl-trimethylammonium chlorides and bromides, compounds of high interest as lysing agents in hematologic analyses. In parallel, the same approach has been used for some commercially available lysing reagent products. While in positive-ion FAB mass spectra the presence of the abundant ions corresponding to the intact quaternary ammonium cations (Q+) is accompanied by the presence of [Q2X]+ (X = Cl, Br) species, in the negative-ion mode cluster ions such as [QX2]- are the sole ionic species that are easily evident. The mechanism for the formation of [Q2X]+ and [QX2]- species has been studied and some suggested explanations are given.
正离子和负离子快原子轰击（FAB）质谱法已被用于表征纯的十二烷基、十四烷基和十六烷基三甲基氯化铵和溴化物，这些化合物作为血液学分析中的裂解剂备受关注。同时，相同的方法也被用于一些市售的裂解试剂产品。在正离子FAB质谱中，对应完整季铵阳离子（Q+）的丰富离子的存在伴随着[Q2X]+（X = Cl、Br）物种的存在，而在负离子模式下，诸如[QX2]-的簇离子是唯一容易显现的离子物种。已对[Q2X]+和[QX2]-物种的形成机制进行了研究，并给出了一些解释建议。
