烯二炔类化合物对艾滋病相关卡波西肉瘤细胞的抗增殖作用。
Antiproliferative effects of enediynes on AIDS-derived Kaposi's sarcoma cells.
作者信息
Corbeil J, Richman D D, Wrasidlo W, Nicolaou K C, Looney D J
机构信息
Department of Pathology, University of California San Diego, La Jolla 92093-0679.
出版信息
Cancer Res. 1994 Aug 15;54(16):4270-3.
We have investigated the antiproliferative and cytotoxic effects of selected enediynes against three Kaposi's sarcoma (KS) cell lines. The enediynes tested were found to be very potent in inhibiting the growth of KS cells. Treatment with concentrations of 10(-10) M or less were capable of producing 50% inhibition of growth. Furthermore, treatment of KS cells with enediynes induced apoptosis in up to 80% of the cells. This unique class of antitumor agents has therapeutic potential for the treatment of KS.
我们研究了所选烯二炔对三种卡波西肉瘤（KS）细胞系的抗增殖和细胞毒性作用。结果发现，所测试的烯二炔在抑制KS细胞生长方面非常有效。用浓度为10^(-10) M或更低的烯二炔处理能够产生50%的生长抑制。此外，用烯二炔处理KS细胞可诱导高达80%的细胞凋亡。这类独特的抗肿瘤药物在治疗KS方面具有治疗潜力。
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