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1
Frequency analysis of tumor-reactive cytotoxic T lymphocytes in peripheral blood of a melanoma patient vaccinated with autologous tumor cells.对接受自体肿瘤细胞疫苗接种的黑色素瘤患者外周血中肿瘤反应性细胞毒性T淋巴细胞的频率分析。
Cancer Immunol Immunother. 1994 Aug;39(2):93-9. doi: 10.1007/BF01525314.
2
Increased non-major histocompatibility complex-restricted lytic activity in melanoma patients vaccinated with cytokine gene-transfected autologous tumor cells.用细胞因子基因转染的自体肿瘤细胞接种的黑色素瘤患者中，非主要组织相容性复合体限制的溶解活性增加。
Cancer Gene Ther. 2000 Jul;7(7):976-84. doi: 10.1038/sj.cgt.7700203.
3
Cloned human cytotoxic T lymphocyte (CTL) lines reactive with autologous melanoma cells. I. In vitro generation, isolation, and analysis to phenotype and specificity.与自体黑色素瘤细胞反应的克隆化人细胞毒性T淋巴细胞（CTL）系。I. 体外生成、分离及表型和特异性分析。
J Immunol. 1984 Jan;132(1):510-9.
4
Melanoma-specific cytotoxic T cells generated from peripheral blood lymphocytes. Implications of a renewable source of precursors for adoptive cellular immunotherapy.从外周血淋巴细胞产生的黑色素瘤特异性细胞毒性T细胞。前体细胞可再生来源对过继性细胞免疫治疗的意义。
Ann Surg. 1989 Aug;210(2):194-202. doi: 10.1097/00000658-198908000-00010.
5
Autologous tumor-specific cytotoxic T lymphocytes in the infiltrate of human metastatic melanomas. Activation by interleukin 2 and autologous tumor cells, and involvement of the T cell receptor.人类转移性黑色素瘤浸润中的自体肿瘤特异性细胞毒性T淋巴细胞。白细胞介素2和自体肿瘤细胞的激活作用以及T细胞受体的参与。
J Exp Med. 1988 Oct 1;168(4):1419-41. doi: 10.1084/jem.168.4.1419.
6
Precursor frequency analysis of human cytolytic T lymphocytes directed against autologous melanoma cells.针对自体黑色素瘤细胞的人细胞毒性T淋巴细胞的前体频率分析。
Int J Cancer. 1992 Jan 21;50(2):289-97. doi: 10.1002/ijc.2910500220.
7
Detection of melanoma-reactive CD4+ HLA-class I-restricted cytotoxic T cell clones with long-term assay and pretreatment of targets with interferon-gamma.通过长期检测及用γ干扰素预处理靶标来检测黑色素瘤反应性CD4 + HLA - I类限制性细胞毒性T细胞克隆。
Cancer Immunol Immunother. 1993 Aug;37(3):187-94. doi: 10.1007/BF01525434.
8
Limited antitumor T cell response in melanoma patients vaccinated with interleukin-2 gene-transduced allogeneic melanoma cells.用白细胞介素-2基因转导的同种异体黑色素瘤细胞接种的黑色素瘤患者中抗肿瘤T细胞反应有限。
Hum Gene Ther. 1996 Oct 20;7(16):1955-63. doi: 10.1089/hum.1996.7.16-1955.
9
Cytotoxic T cell lines recognize autologous and allogeneic melanomas with shared or cross-reactive HLA-A.细胞毒性T细胞系可识别具有共享或交叉反应性HLA-A的自体和同种异体黑色素瘤。
Cancer Immunol Immunother. 1992;34(6):419-23. doi: 10.1007/BF01741754.
10
A case report: immune responses and clinical course of the first human use of granulocyte/macrophage-colony-stimulating-factor-transduced autologous melanoma cells for immunotherapy.病例报告：首例人类使用粒细胞/巨噬细胞集落刺激因子转导的自体黑色素瘤细胞进行免疫治疗的免疫反应及临床病程
Cancer Immunol Immunother. 1997 Mar;44(1):10-20. doi: 10.1007/s002620050349.

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Targeted Cancer Therapy with Tumor Necrosis Factor-Alpha.肿瘤坏死因子-α的靶向癌症治疗
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[Prostate carcinoma: vaccination as a new option for treatment].[前列腺癌：疫苗接种作为一种新的治疗选择]
Urologe A. 2012 Jan;51(1):44-9. doi: 10.1007/s00120-011-2712-6.
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Dendritic cell vaccination and immune monitoring.树突状细胞疫苗接种与免疫监测。
Cancer Immunol Immunother. 2008 Oct;57(10):1559-68. doi: 10.1007/s00262-008-0553-y. Epub 2008 Jul 10.
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In situ detection of antigen-specific T cells in cryo-sections using MHC class I tetramers after dendritic cell vaccination of melanoma patients.黑色素瘤患者进行树突状细胞疫苗接种后，使用MHC I类四聚体在冷冻切片中对抗原特异性T细胞进行原位检测。
Cancer Immunol Immunother. 2007 Oct;56(10):1667-76. doi: 10.1007/s00262-007-0304-5. Epub 2007 Apr 18.
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High frequency of antitumor T cells in the blood of melanoma patients before and after vaccination with tumor antigens.黑色素瘤患者接种肿瘤抗原前后血液中抗肿瘤T细胞的高频率。
J Exp Med. 2005 Jan 17;201(2):241-8. doi: 10.1084/jem.20041379.
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Immune responses to tumour antigens: implications for antigen specific immunotherapy of cancer.对肿瘤抗原的免疫反应：对癌症抗原特异性免疫治疗的启示。
J Clin Pathol. 2001 Sep;54(9):669-74. doi: 10.1136/jcp.54.9.669.
7
Evaluation of the modified ELISPOT assay for gamma interferon production in cancer patients receiving antitumor vaccines.对接受抗肿瘤疫苗的癌症患者中γ干扰素产生情况的改良酶联免疫斑点测定法的评估。
Clin Diagn Lab Immunol. 2000 Mar;7(2):145-54. doi: 10.1128/CDLI.7.2.145-154.2000.
8
Identification of NY-ESO-1 epitopes presented by human histocompatibility antigen (HLA)-DRB4*0101-0103 and recognized by CD4(+) T lymphocytes of patients with NY-ESO-1-expressing melanoma.鉴定由人类组织相容性抗原（HLA）-DRB4*0101-0103呈递、并被表达NY-ESO-1的黑色素瘤患者的CD4(+) T淋巴细胞识别的NY-ESO-1表位。
J Exp Med. 2000 Feb 21;191(4):625-30. doi: 10.1084/jem.191.4.625.
9
Vaccination with IL-7 gene-modified autologous melanoma cells can enhance the anti-melanoma lytic activity in peripheral blood of patients with a good clinical performance status: a clinical phase I study.用白细胞介素-7基因修饰的自体黑色素瘤细胞进行疫苗接种可增强临床状态良好的患者外周血中的抗黑色素瘤溶解活性：一项I期临床研究。
Br J Cancer. 1998 Jun;77(11):1907-16. doi: 10.1038/bjc.1998.317.
10
Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma.一种用于治疗转移性黑色素瘤患者的合成肽疫苗的免疫学和治疗学评估
Nat Med. 1998 Mar;4(3):321-7. doi: 10.1038/nm0398-321.

本文引用的文献

1
Defined antigens recognized by T lymphocytes on human tumors.T淋巴细胞识别的人类肿瘤上的特定抗原。
Curr Opin Oncol. 1993 Nov;5(6):1043-8. doi: 10.1097/00001622-199311000-00016.
2
Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.用于确定免疫活性细胞频率的有限稀释分析。I. 数据分析。
J Immunol. 1981 Apr;126(4):1614-9.
3
Quantitative assessment of the pool size and subset distribution of cytolytic T lymphocytes within human resting or alloactivated peripheral blood T cell populations.对人静止或同种异体激活的外周血T细胞群体中细胞毒性T淋巴细胞的库大小和亚群分布进行定量评估。
J Exp Med. 1983 Aug 1;158(2):571-85. doi: 10.1084/jem.158.2.571.
4
Selective reduction of donor-specific cytotoxic T lymphocyte precursors in patients with a well-functioning kidney allograft.在具有功能良好的肾移植受者中选择性减少供体特异性细胞毒性T淋巴细胞前体
Transplantation. 1987 Mar;43(3):384-9. doi: 10.1097/00007890-198703000-00013.
5
Analysis of the alloreactive T cell repertoire in man. I. Differences in precursor frequency for cytotoxic T cell responses against allogeneic MHC molecules in unrelated individuals.人类同种异体反应性T细胞库分析。I. 无关个体中针对同种异体MHC分子的细胞毒性T细胞反应前体频率的差异。
Transplantation. 1987 May;43(5):699-703. doi: 10.1097/00007890-198705000-00019.
6
Production of stable cytolytic T-cell clones directed against autologous human melanoma.针对自体人黑色素瘤的稳定细胞溶解性T细胞克隆的产生。
Int J Cancer. 1987 Mar 15;39(3):390-6. doi: 10.1002/ijc.2910390320.
7
Antigenic heterogeneity of a human melanoma tumor detected by autologous CTL clones.通过自体CTL克隆检测到的人类黑色素瘤肿瘤的抗原异质性。
Eur J Immunol. 1988 May;18(5):671-6. doi: 10.1002/eji.1830180503.
8
Human cytomegalovirus-specific cytotoxic T cells: their precursor frequency and stage specificity.人巨细胞病毒特异性细胞毒性T细胞：其前体频率和阶段特异性。
Eur J Immunol. 1988 Feb;18(2):269-75. doi: 10.1002/eji.1830180214.
9
Lysis of human melanoma cells by autologous cytolytic T cell clones. Identification of human histocompatibility leukocyte antigen A2 as a restriction element for three different antigens.自体细胞溶解性T细胞克隆对人黑色素瘤细胞的溶解作用。将人类组织相容性白细胞抗原A2鉴定为三种不同抗原的限制元件。
J Exp Med. 1989 Sep 1;170(3):797-810. doi: 10.1084/jem.170.3.797.
10
Analysis of cytotoxic T cell precursor frequencies directed against individual HLA-A and -B alloantigens.针对个体HLA - A和 - B同种异体抗原的细胞毒性T细胞前体频率分析。
J Immunol Methods. 1989 Jul 6;121(1):39-45. doi: 10.1016/0022-1759(89)90417-1.

对接受自体肿瘤细胞疫苗接种的黑色素瘤患者外周血中肿瘤反应性细胞毒性T淋巴细胞的频率分析。

Frequency analysis of tumor-reactive cytotoxic T lymphocytes in peripheral blood of a melanoma patient vaccinated with autologous tumor cells.

作者信息

Herr W, Wölfel T, Heike M, Meyer zum Büschenfelde K H, Knuth A

机构信息

I. Medizinische Klinik und Poliklinik, Johannes Gutenberg-Universität Mainz, Germany.

出版信息

Cancer Immunol Immunother. 1994 Aug;39(2):93-9. doi: 10.1007/BF01525314.

DOI:10.1007/BF01525314
PMID:8044834
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11038030/
Abstract

A limiting-dilution assay was developed and used to determine the frequency of autologous tumor-reactive cytotoxic T lymphocytes (CTL) in peripheral blood of a melanoma patient MZ2, who has been free of detectable disease since several years. In this patient, the frequencies of tumor-reactive CTL spontaneously varied only by a factor of 1.5. After vaccinations with autologous mutagenized and lethally irradiated tumor cells a two- to tenfold increase in frequencies of tumor-reactive CTL was found within the first 2 weeks. Thereafter, CTL frequencies returned to values measured prior to vaccinations. We conclude, that the limiting-dilution assay applied in this study can detect changes in the T cell response to autologous tumor cells. The frequency of tumor-reactive CTL determined with this approach can serve as an immunological parameter for monitoring the T cell response to autologous tumor cells in individual cancer patients receiving tumor cell vaccinations.

摘要

开发了一种有限稀释分析法，并用于测定黑色素瘤患者MZ2外周血中自体肿瘤反应性细胞毒性T淋巴细胞（CTL）的频率，该患者已多年无疾病可检测。在该患者中，肿瘤反应性CTL的频率自发变化仅为1.5倍。在用自体诱变和致死性照射的肿瘤细胞进行疫苗接种后，在最初2周内发现肿瘤反应性CTL的频率增加了2至10倍。此后，CTL频率恢复到接种疫苗前测得的值。我们得出结论，本研究中应用的有限稀释分析法可以检测T细胞对自体肿瘤细胞反应的变化。用这种方法测定的肿瘤反应性CTL频率可作为免疫参数，用于监测接受肿瘤细胞疫苗接种的个体癌症患者中T细胞对自体肿瘤细胞的反应。