Coulie P G, Van Pel A
Ludwig Institute for Cancer Research, Brussels, Belgium.
Curr Opin Oncol. 1993 Nov;5(6):1043-8. doi: 10.1097/00001622-199311000-00016.
Several independent groups have developed methods aimed at identifying antigens that are expressed on human tumors and can be recognized by T lymphocytes. The positively identified antigens can be presently classified as follows: 1) antigens derived from genes whose functions are still unknown that are expressed in significant proportions of tumors of various histologic types but not expressed in most normal tissues, 2) differentiation antigens expressed in melanomas, 3) mucins, 4) viral antigens, and 5) products of abnormal genes expressed in tumors. These results are presented with explanations about the methodologies used to identify these antigens in the perspective of their use in immunotherapy.
几个独立的研究小组已经开发出一些方法，旨在识别在人类肿瘤上表达且能被T淋巴细胞识别的抗原。目前，已确定的阳性抗原可分类如下：1）来自功能仍未知的基因的抗原，这些抗原在各种组织学类型的肿瘤中大量表达，但在大多数正常组织中不表达；2）黑色素瘤中表达的分化抗原；3）粘蛋白；4）病毒抗原；5）肿瘤中表达的异常基因产物。本文将结合免疫治疗应用的视角，对用于识别这些抗原的方法进行解释，并展示这些研究结果。
