人类皮肤中的酪氨酸酶活性。种族和年龄对新生儿的影响。
Tyrosinase activity in human skin. Influence of race and age in newborns.
作者信息
Pomerantz S H, Ances I G
出版信息
J Clin Invest. 1975 May;55(5):1127-31. doi: 10.1172/JCI108014.
Abstract
Tyrosinase has been measured in homogenates of foreskins from newborn babies. The tyrosine hydroxylation reaction is dependent upon 3,4-dihydroxyphenylalanine as a cosubstrate, and the Km for tyrosine is 0.15 mM, similar to the value observed for other mammalian tyrosinases. The mean enzyme activity for black babies (n = 169) is about two and one-fourth times that for white babies (n = 82). For white babies there is a significant correlation between age at circumcision and tyrosinase activity. For black babies this correlation becomes significant when four individuals with extremely high tyrosinase activities are omitted from the series.
摘要
已对新生儿包皮匀浆中的酪氨酸酶进行了测定。酪氨酸羟化反应依赖于3,4 - 二羟基苯丙氨酸作为共底物，酪氨酸的米氏常数（Km）为0.15 mM，与其他哺乳动物酪氨酸酶所观察到的值相似。黑人婴儿（n = 169）的平均酶活性约为白人婴儿（n = 82）的二又四分之一倍。对于白人婴儿，包皮环切术时的年龄与酪氨酸酶活性之间存在显著相关性。对于黑人婴儿，当从该系列中剔除四名酪氨酸酶活性极高的个体后，这种相关性变得显著。
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