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[着色性干皮病细胞中适应性DNA修复的缺失]

[Absence of adaptive DNA repair in xeroderma pigmentosum cells].

作者信息

Vasil'eva I M, Sinel'shchikova T A, L'vova G N, Meliksetova I A, Zasukhina G D

出版信息

Genetika. 1994 Apr;30(4):484-7.

PMID:8045399
Abstract

Adaptive repair is the restoration of chemically induced DNA breaks in human fibroblasts previously gamma-irradiated at low doses. The adaptive repair in xeroderma pigmentosum (XP) cells was compared to that in normal human fibroblasts. The obtained results suggest that the repair is inducible and error-free. Adaptive repair was not found in XP cells in experiments with 4-NQO. This is correlated with the presence of an excision repair defect in XP.

摘要

适应性修复是指对先前经低剂量γ射线辐照的人成纤维细胞中化学诱导的DNA断裂进行修复。将着色性干皮病(XP)细胞中的适应性修复与正常人成纤维细胞中的进行了比较。所得结果表明这种修复是可诱导且无差错的。在使用4-硝基喹啉-1-氧化物的实验中,未在XP细胞中发现适应性修复。这与XP中存在切除修复缺陷相关。

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