钙通道阻滞剂和沙丁胺醇对实验性诱导大鼠早产的延迟作用。

Delay of experimentally induced preterm labour in rats with calcium channel blockers and salbutamol.

作者信息

Sharma S, Gupta U

机构信息

Department of Pharmacology, Maulana Azad Medical College, New Delhi, India.

出版信息

Indian J Exp Biol. 1994 Feb;32(2):109-12.

PMID:8045609

Abstract

The effect of some calcium channel blockers on spontaneous activity of uterine strips obtained from 16 day pregnant rats was observed and compared with salbutamol. Nifedipine (2.9, 14 nM), verapamil (2, 10 nM) and diltiazem (11,22nM) both at low and high doses significantly abolished spontaneous contractions which was gradual and persistent. However, salbutamol (4.2, 21 nM) abolished spontaneous activity immediately but the response was shortlived. The effect of these agents was also investigated on experimentally induced preterm labour in rats (ovariectomized on day 16 of pregnancy). In the control group only 21% of foetuses were retained at the end of 48 hr. Nifedipine, verapamil, diltiazem and salbutamol administered ip 8 hourly protected 91%, 90%, 78% and 61% of foetuses from delivery at 48 hr respectively. The rank order of efficacy was nifedipine > verapamil > diltiazem > salbutamol.

摘要

观察了某些钙通道阻滞剂对从怀孕16天的大鼠获得的子宫肌条自发活动的影响，并与沙丁胺醇进行了比较。硝苯地平（2.9、14 nM）、维拉帕米（2、10 nM）和地尔硫䓬（11、22 nM）的低剂量和高剂量均显著消除了自发收缩，这种消除是渐进且持久的。然而，沙丁胺醇（4.2、21 nM）立即消除了自发活动，但反应是短暂的。还研究了这些药物对实验性诱导的大鼠早产（在怀孕第16天进行卵巢切除术）的影响。在对照组中，48小时结束时仅21%的胎儿被保留。每8小时腹腔注射一次的硝苯地平、维拉帕米、地尔硫䓬和沙丁胺醇分别使48小时时91%、90%、78%和61%的胎儿免于分娩。疗效的顺序为硝苯地平>维拉帕米>地尔硫䓬>沙丁胺醇。