Smithson G, Beamer W G, Shultz K L, Christianson S W, Shultz L D, Kincade P W
Oklahoma Medical Research Foundation, Oklahoma City 73104.
J Exp Med. 1994 Aug 1;180(2):717-20. doi: 10.1084/jem.180.2.717.
Interleukin 7 (IL-7) responsive B lineage precursors were greatly expanded in genetically hypogonadal female (HPG/Bm-hpg/hpg) mice that have a secondary deficiency in gonadal steroidogenesis. Estrogen replacement in these mice resulted in a dose-dependent reduction in B cell precursors. More modest increases were documented in genetically normal mice that were surgically castrated. These findings complement other recent observations that B lymphopoiesis selectively declines in pregnant or estrogen-treated animals. Sex steroids have long been known to influence such disparate processes as bone physiology and tumor growth, in addition to their importance for reproductive function. We now show that these hormones are important negative regulators of B lymphopoiesis.
白细胞介素7（IL-7）反应性B系前体细胞在性腺类固醇生成继发性缺陷的遗传性性腺功能减退雌性（HPG/Bm-hpg/hpg）小鼠中大量扩增。对这些小鼠进行雌激素替代治疗后，B细胞前体细胞数量呈剂量依赖性减少。在接受手术去势的基因正常小鼠中，也观察到了较为适度的增加。这些发现补充了近期的其他观察结果，即在怀孕或接受雌激素治疗的动物中，B淋巴细胞生成会选择性下降。长期以来，人们已知性类固醇除了对生殖功能至关重要外，还会影响诸如骨骼生理和肿瘤生长等不同过程。我们现在表明，这些激素是B淋巴细胞生成的重要负调节因子。
