Sato S
Second Department of Internal Medicine, Nagoya City University Medical School.
Nihon Rinsho. 1994 Jun;52(6):1550-5.
Since the introduction of bronchoalveolar lavage (BAL) by Reynolds and Newball in 1974, this procedure has been used to characterize the cellular and soluble components of alveolar lining fluid in many interstitial lung diseases. We reviewed BAL fluid findings of clinical and pathophysiologic researches in patients with pulmonary sarcoidosis. Moreover, our recent data about soluble CD4 molecule (sCD4) and soluble CD8 molecule (sCD8) were also described. The sarcoidosis patients had the significantly higher level of sCD4 in BAL fluid compared with normal subjects. The level of sCD8 in serum in active sarcoidosis was significantly higher than that in normal subjects. Furthermore, significant correlation between the levels of serum sCD8 and ACE was observed in sarcoidosis.
自1974年雷诺兹（Reynolds）和纽博尔（Newball）引入支气管肺泡灌洗（BAL）以来，该方法已被用于表征多种间质性肺疾病中肺泡内衬液的细胞成分和可溶性成分。我们回顾了肺结节病患者临床和病理生理学研究中的BAL液检查结果。此外，还描述了我们最近关于可溶性CD4分子（sCD4）和可溶性CD8分子（sCD8）的数据。与正常受试者相比，结节病患者BAL液中的sCD4水平显著更高。活动期结节病患者血清中的sCD8水平显著高于正常受试者。此外，在结节病患者中观察到血清sCD8水平与血管紧张素转换酶（ACE）水平之间存在显著相关性。
