荻草谷胱甘肽对溴苯诱导的小鼠肝毒性的保护作用。

Hispidulin protection against hepatotoxicity induced by bromobenzene in mice.

作者信息

Ferrándiz M L, Bustos G, Payá M, Gunasegaran R, Alcaraz M J

机构信息

Department of Pharmacology, University of Valencia, Spain.

出版信息

Life Sci. 1994;55(8):PL145-50. doi: 10.1016/0024-3205(94)00490-0.

DOI:10.1016/0024-3205(94)00490-0

PMID:8046988

Abstract

The effects of the natural flavonoid hispidulin (6-methoxy-5,7,4'-trihydroxyflavone) on bromobenzene-induced hepatotoxicity in mice were investigated. We found a correlation between liver injury and hepatic lipid peroxidation besides a strong liver glutathione depletion due to the toxicant. Hispidulin at doses between 50 and 150 mg/kg i.p. compared favourably with the reference compound N-acetyl-L-cysteine for inhibition of liver injury and lipid peroxidation. The flavonoid at the highest dose tested was also able to counteract reduced glutathione depletion induced by bromobenzene in starved mice. These hepatoprotective effects can be related to the antioxidant properties of hispidulin.

摘要

研究了天然黄酮类化合物滨蓟黄素（6-甲氧基-5,7,4'-三羟基黄酮）对溴苯诱导的小鼠肝毒性的影响。我们发现，除了由于毒物导致肝脏谷胱甘肽大量消耗外，肝损伤与肝脏脂质过氧化之间存在相关性。腹腔注射剂量为50至150 mg/kg的滨蓟黄素，在抑制肝损伤和脂质过氧化方面与参考化合物N-乙酰-L-半胱氨酸相比具有优势。所测试的最高剂量的黄酮类化合物还能够对抗饥饿小鼠中溴苯诱导的谷胱甘肽消耗减少。这些肝脏保护作用可能与滨蓟黄素的抗氧化特性有关。