不同品系大鼠外周神经切断后起源于神经瘤的初级传入纤维中持续性放电发生率的变异性。

Variability in the occurrence of ongoing discharges in primary afferents originating in the neuroma after peripheral nerve section in different strains of rats.

作者信息

Hao J X, Wiesenfeld-Hallin Z

机构信息

Department of Medical Laboratory Science, Huddinge University Hospital, Karolinska Institute, Sweden.

出版信息

Neurosci Lett. 1994 Mar 14;169(1-2):119-21. doi: 10.1016/0304-3940(94)90370-0.

DOI:10.1016/0304-3940(94)90370-0

PMID:8047264

Abstract

Activity in myelinated (A) afferents was recorded proximal to the neuroma 7-14 days after ligation and section of the sciatic nerve in spontaneously hypertensive (SHR), Wistar-Kyoto (WK) and Sprague-Dawley (SD) rats. Ongoing activity was recorded in 83% of nerve filaments in WK and in 89% in SHR rats. In contrast, only 16% of filaments recorded in SD rats had ongoing activity although the silent filaments could be activated by mechanical stimulation of the neuroma. Thus, the ability of the neuroma to generate ongoing activity in rats may be subject to strain-related genetic control.

摘要

在自发性高血压大鼠（SHR）、Wistar-Kyoto大鼠（WK）和Sprague-Dawley大鼠（SD）中，在结扎并切断坐骨神经7 - 14天后，在神经瘤近端记录有髓鞘（A）传入纤维的活动。在WK大鼠的神经细丝中，83%记录到持续活动；在SHR大鼠中，这一比例为89%。相比之下，在SD大鼠中记录的细丝只有16%有持续活动，尽管通过机械刺激神经瘤可激活无活动的细丝。因此，神经瘤在大鼠中产生持续活动的能力可能受品系相关的基因控制。