延髓头端腹外侧加压区：去大脑大鼠的电生理研究

The medullary rostral ventrolateral pressor region: an electrophysiological study in decerebrate rat.

作者信息

Frugière A, Barillot J C

机构信息

Laboratoire de Neurobiologie et Neurophysiologie Fonctionnelles, ERS CNRS 61, Faculté des Sciences et Techniques de Saint-Jérome, Marseille, France.

出版信息

Neurosci Lett. 1994 Mar 14;169(1-2):191-4. doi: 10.1016/0304-3940(94)90389-1.

DOI:10.1016/0304-3940(94)90389-1

PMID:8047281

Abstract

Decerebrate rat was used to study the discharge pattern of barosensitive neurons. This preparation avoids general anesthesia and suppresses painful sensations of the animal. Twenty-eight spontaneously active units were recorded in the rostral ventrolateral region of the medulla (RVLM). Six units had projections to the spinal cord (bulbospinal) and 22 were not antidromically activated by spinal cord stimulation (NAA). Transient hypertension induced by intravenous injection of noradrenaline depressed the activity of 21 units, and increased activity of 7, regardless of axonal destination. Unlike anesthetized rat, the decerebrate rat possesses spontaneously active neurons with excitatory response to hypertension.

摘要

去大脑大鼠被用于研究压力敏感神经元的放电模式。这种制备方法避免了全身麻醉，并抑制了动物的疼痛感觉。在延髓头端腹外侧区（RVLM）记录到28个自发放电单位。其中6个单位投射到脊髓（延髓脊髓型），22个单位不能被脊髓刺激逆向激活（非逆向激活型）。静脉注射去甲肾上腺素诱发的短暂性高血压使21个单位的活动受到抑制，7个单位的活动增强，而与轴突的投射部位无关。与麻醉大鼠不同，去大脑大鼠拥有对高血压有兴奋反应的自发放电神经元。