Trick G L, Kaskie B, Steinman S B
School of Optometry, University of Montreal, Quebec.
Optom Vis Sci. 1994 Apr;71(4):242-5. doi: 10.1097/00006324-199404000-00002.
In order to obtain a better understanding of the pathophysiology of visual impairment in Parkinson's disease (PD), orientation and motion discrimination were investigated in PD patients.
Orientation and motion discrimination thresholds were assessed psychophysically in PD patients with normal cognition (N = 11) and compared to results for age-matched controls (N = 22).
PD patients exhibited a significant deficit in orientation discrimination for horizontal but not for vertical gratings. Also, motion discrimination thresholds were elevated significantly in PD patients. No significant correlations were found between motion and orientation discrimination thresholds.
Our results indicate that PD patients exhibit significant visual dysfunction in the absence of cognitive impairment supporting the contention that neural dysfunction in PD is more generalized than previously realized. The results provide further evidence of an orientation selective visual deficit in PD and show that the ability to discriminate global motion is also attenuated in PD.
为了更好地理解帕金森病（PD）患者视力损害的病理生理学，对PD患者的定向和运动辨别能力进行了研究。
对认知正常的PD患者（N = 11）进行心理物理学评估，测定其定向和运动辨别阈值，并与年龄匹配的对照组（N = 22）的结果进行比较。
PD患者在水平光栅的定向辨别上表现出显著缺陷，而在垂直光栅上则没有。此外，PD患者的运动辨别阈值显著升高。运动和定向辨别阈值之间未发现显著相关性。
我们的结果表明，PD患者在没有认知障碍的情况下表现出明显的视觉功能障碍，支持了PD患者神经功能障碍比之前认识到的更为普遍的观点。这些结果进一步证明了PD患者存在定向选择性视觉缺陷，并表明PD患者辨别整体运动的能力也有所减弱。
