Larsson L I, Sundler F, Grimelius L, Håkanson R, Buffa R, Solcia E
Virchows Arch A Pathol Anat Histol. 1975;365(3):179-84. doi: 10.1007/BF00434036.
Material from eight peptide hormone-secreting tumours, extirpated from the pancreas or from the antrum-duodenum region, was examined. Four of the patients had the clinical manifestations of the Zollinger-Ellison syndrome, two showed the features of an insulin-secreting tumour and one had a glucagonoma. Gastrin-producing cells, identified by immunohistochemistry, were found in five of the tumours. These cells displayed a varying degree of formaldehyde-ozone-induced fluorescence. This agrees with previous observations on the gastrin cell of human antral and duodenal mucosa. From model experiments, formaldehyde-ozone-induced fluorescence is thought to reflect the presence of peptides having tryptophan in the NH2-terminal position. The nature of this peptide in gastrin-producing cells is unknown.
对从胰腺或胃窦 - 十二指肠区域切除的8个分泌肽类激素的肿瘤组织进行了检查。其中4例患者有佐林格 - 埃利森综合征的临床表现，2例表现为胰岛素分泌瘤的特征，1例患有胰高血糖素瘤。通过免疫组织化学鉴定，在5个肿瘤中发现了产生胃泌素的细胞。这些细胞呈现出不同程度的甲醛 - 臭氧诱导荧光。这与先前对人胃窦和十二指肠黏膜胃泌素细胞的观察结果一致。从模型实验来看，甲醛 - 臭氧诱导荧光被认为反映了在NH2末端位置含有色氨酸的肽的存在。产生胃泌素的细胞中这种肽的性质尚不清楚。
