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[N-棕榈酰乙醇胺和N-硬脂酰乙醇胺对转移性Lewis肺癌小鼠组织脂质过氧化的影响]

[Effect of N-palmitoyl- and N-stearoylethanolamines on lipid peroxidation in mouse tissues in metastatic Lewis carcinoma].

作者信息

Gulaia N M, Smirnov I M, Shmal'ko Iu P, Mel'nik A A, Mel'nik S N

出版信息

Ukr Biokhim Zh (1978). 1993 Nov-Dec;65(6):96-101.

PMID:8048188
Abstract

The ability of two-cell minor lipid components: N-palmitoyl- and N-stearoylethanolamines to influence the Lewis lung carcinoma metastases has been studied. It is shown that these compounds decrease the quantity and the volume of metastases. Acyl derivatives of ethanolamine inhibit simultaneously the process of lipid peroxidation. Mice C57 B1/6 were intraperitonealy injected labeled 3H-N-stearoylethanolamine. Localization of this radioactive label in some organs of the animals was studied.

摘要

研究了两种细胞微量脂质成分

N-棕榈酰乙醇胺和N-硬脂酰乙醇胺影响Lewis肺癌转移的能力。结果表明,这些化合物可减少转移灶的数量和体积。乙醇胺的酰基衍生物同时抑制脂质过氧化过程。给C57 B1/6小鼠腹腔注射标记的3H-N-硬脂酰乙醇胺,研究了该放射性标记在动物某些器官中的定位。

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