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[锂、卡马西平和塞替派对大鼠离体脑组织中二酰甘油的影响]

[Effect of lithium, carbamazepine, and setiptiline on diacylglycerol in rat brain ex vivo].

作者信息

Kodama H

机构信息

Department of Psychiatry, Kawasaki Medical School, Kurashiki, Japan.

出版信息

Nihon Shinkei Seishin Yakurigaku Zasshi. 1994 Feb;14(1):33-8.

PMID:8048280
Abstract

The effect of lithium on diacylglycerol (DAG), which is an intracellular second messenger, was compared with those of carbamazepine and setiptiline ex vivo through phosphatidylinositol turnover (PI response). Consequently, (1) PI response cycling by stimulation of norepinephrine participated in the alpha 1 receptor. (2) DAG accumulation in rat brain exhibited a biphasic pattern. (3) Lithium elevated DAG accumulation at 30 seconds after stimulation by norepinephrine. (4) Carbamazepine did not affect DAG accumulation. (5) Setiptiline decreased DAG accumulation at 30 minutes after stimulation by norepinephrine.

摘要

通过磷脂酰肌醇周转率（PI反应），在体外比较了锂对作为细胞内第二信使的二酰基甘油（DAG）的作用与卡马西平和塞替普汀的作用。结果如下：（1）通过去甲肾上腺素刺激引起的PI反应循环参与α1受体。（2）大鼠脑中DAG的积累呈现双相模式。（3）锂在去甲肾上腺素刺激后30秒时升高了DAG的积累。（4）卡马西平不影响DAG的积累。（5）塞替普汀在去甲肾上腺素刺激后30分钟时降低了DAG的积累。

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