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[纤维连接蛋白在妊娠高血压/先兆子痫及胎盘功能不全中的批判性评估]

[Critical evaluation of fibronectin in pregnancy-induced hypertension/pre-eclampsia and placental insufficiency].

作者信息

Lehnen H, el Magd M, Schöngen R N, Reinecke T

机构信息

Frauenklinik, RWTH Aachen.

出版信息

Zentralbl Gynakol. 1994;116(6):352-7.

PMID:8048291
Abstract
  1. Fibronectin does not correlate with the grade of proteinuria. 2. Fibronectin does not correlate with birth weight. 3. Fibronectin level is not elevated in pregnancy-induced hypertension and preeclampsia. 4. Fibronectin level is elevated in cases of preeclampsia, combined with chronic placental insufficiency respectively intrauterine growth retardation. 5. There is a statistic significant difference between pregnancy-induced hypertension/preeclampsia with or with out placental insufficiency. 6. Extremely problematic pregnancies ended in all pregnancies with values of fibronectin above 0.4 g/l in caesarean section without knowledge of the elevated fibronectin level at the time of operation. 7. In the group of pregnancy-induced hypertension the fibronectin level is elevated in relation to control group. This increase is particularly evident, if a placental insufficiency is concontinant with preeclampsia.
摘要
  1. 纤连蛋白与蛋白尿分级无关。2. 纤连蛋白与出生体重无关。3. 妊娠高血压和子痫前期患者的纤连蛋白水平未升高。4. 子痫前期合并慢性胎盘功能不全或宫内生长受限的病例中,纤连蛋白水平升高。5. 伴有或不伴有胎盘功能不全的妊娠高血压/子痫前期之间存在统计学显著差异。6. 在剖宫产时,所有妊娠中,当纤连蛋白值高于0.4 g/l时,妊娠结局极其不良,而手术时并不知道纤连蛋白水平升高。7. 在妊娠高血压组中,与对照组相比,纤连蛋白水平升高。如果子痫前期伴有胎盘功能不全,这种升高尤为明显。

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