Pimentel J C, Alves M C
Serviço de Anatomia Patológica do Hospital de Santa Maria, Lisboa.
Acta Med Port. 1994 Apr;7(4):237-41.
Granulomatous inflammation is a well recognized environmentally produced skin disease. Four cases of sarcoid-type skin granuloma associated with foreign materials introduced into the skin are reported. In two of the cases, caused by windscreen glass debris and gunpowder, there were multiple lesions which revealed a tumor-like appearance several years after the accident. In a third case, associated with occupational exposure to cork dust, the granulomatous lesions was unique and formerly misdiagnosed as malignant. The skin lesions caused by gunpowder and cork dust coexisted with lung lesions caused by the inhalation of the same materials, which were identified in the histological sections with appropriate methods. The fourth case, caused by sea-urchin spines, revealed a progressive reduction in the latency period between the spine injury and granuloma formation. The relationship between the skin and lung lesions are discussed as well as the role of the foreign materials within the lesions.
肉芽肿性炎症是一种公认的由环境因素导致的皮肤病。本文报告了4例与皮肤内异物相关的结节病样皮肤肉芽肿病例。其中2例分别由挡风玻璃碎片和火药引起，事故发生数年之后出现了多个呈肿瘤样外观的损害。第3例与职业性接触软木尘有关，肉芽肿性损害较为独特，曾被误诊为恶性肿瘤。火药和软木尘引起的皮肤损害与吸入相同物质导致的肺部损害并存，可通过适当的组织学方法在切片中得以识别。第4例由海胆刺引起，显示出从刺损伤到肉芽肿形成的潜伏期逐渐缩短。本文还讨论了皮肤与肺部损害之间的关系以及异物在损害中的作用。
