Yamamoto O, Matsunaga Y, Haga N, Itoh Z
Gastrointestinal Research Laboratories, Gunma University, Maebashi, Japan.
Am J Physiol. 1994 Jul;267(1 Pt 1):G129-34. doi: 10.1152/ajpgi.1994.267.1.G129.
Gastric acidification at pH 1.0 strongly inhibits the spontaneously occurring and motilin-induced phase III contractions in canine and human stomach. In this study, we examined inhibition by gastric acidification in dogs following gastrojejunostomy, truncal vagotomy, and antrectomy. As a result, gastric acidification with 0.1 N HCl solution at pH 1.0 for 30 min at a rate of 1.0 ml/min significantly inhibited motilin-induced phase III activity to 23.5 +/- 5.9% of the control in the normal intact dogs and to 17.2 +/- 3.4% in the gastrojejunostomized dogs. In the antrectomized dogs, gastric acidification did not significantly inhibit the action of motilin (81.7 +/- 10%), but, in the vagotomized dogs, gastric acidification inhibited the action of motilin to 72.0 +/- 4.9%; the inhibition was much weaker than in the intact and gastrojejunostomized dogs but was significant. The duodenal acidification had no effect at all on the action of motilin (94.6 +/- 12.5%) in the gastrojejunostomized dogs. These findings strongly suggest the existence of a vagovagal reflex in the inhibition of motilin-induced phase III contractions by gastric antral acidification, although the involvement of sympathetic regulation cannot be completely ruled out.
pH值为1.0时的胃酸化会强烈抑制犬类和人类胃中自发出现的以及胃动素诱导的III期收缩。在本研究中，我们检测了胃空肠吻合术、迷走神经切断术和胃窦切除术后犬类胃酸化的抑制作用。结果，在正常完整的犬类中，以1.0毫升/分钟的速度用pH值为1.0的0.1N HCl溶液进行30分钟的胃酸化，可将胃动素诱导的III期活性显著抑制至对照组的23.5±5.9%，在胃空肠吻合术犬中则为17.2±3.4%。在胃窦切除的犬类中，胃酸化并未显著抑制胃动素的作用（81.7±10%），但在迷走神经切断的犬类中，胃酸化将胃动素的作用抑制至72.0±4.9%；这种抑制作用比完整和胃空肠吻合术犬类中的要弱得多，但具有显著性。十二指肠酸化对胃空肠吻合术犬类中胃动素的作用完全没有影响（94.6±12.5%）。这些发现有力地表明，胃窦酸化抑制胃动素诱导的III期收缩存在迷走神经反射，尽管不能完全排除交感神经调节的参与。
