Itoh Z, Takeuchi S, Aizawa I, Couch E F
Gastroenterol Jpn. 1977;12(4):284-8. doi: 10.1007/BF02776796.
The interaction between motilin, pentagastrin and feeding was investigated during the interdigestive gastric motor state in 4 healthy conscious dogs. We confirmed previous reports that an i.v. infusion of synthetic motilin always induced a pattern precisely like that of the naturally-occurring interdigestive contractions of the stomach. Pentagastrin inhibited the occurrence of the interdigestive contractions at dose between 0.2-1.6 microgram/kg-hr; this inhibition had a dose-related relationship to the occurrence of the motilin-induced contractions. The ingestion of food strongly inhibited the occurrence of not only the natually-occurring contractions but also the motilin-induced contractions in the stomach and changed the motor pattern to the digestive one. These findings strongly support our hypothesis that the interdigestive contractions in the dog are, at least in part, under the control of motilin. Furthermore, it should be emphasized that pentagastrin not always stimulates gastric motor activity but conversely, in the interdigestive state it inhibits movements characteristic of that condition and replaces them with the digestive pattern.
在4只清醒健康犬的消化间期胃运动状态下，研究了胃动素、五肽胃泌素与进食之间的相互作用。我们证实了先前的报道，即静脉输注合成胃动素总是诱导出一种与胃自然发生的消化间期收缩模式完全相同的模式。五肽胃泌素在剂量为0.2 - 1.6微克/千克·小时之间时抑制消化间期收缩的发生；这种抑制与胃动素诱导的收缩发生呈剂量相关关系。进食不仅强烈抑制胃中自然发生的收缩，也抑制胃动素诱导的收缩，并将运动模式转变为消化模式。这些发现有力地支持了我们的假设，即犬的消化间期收缩至少部分受胃动素控制。此外，应该强调的是，五肽胃泌素并非总是刺激胃运动活动，相反，在消化间期状态下，它抑制该状态下特有的运动，并将其替换为消化模式。
