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[硬膜外血贴治疗腰穿后头痛。产科动脉导管未闭意外硬膜穿孔6周后的成功治疗]

[Epidural blood patch for the treatment of postspinal puncture headache. Successful therapy after 6 weeks following accidental dura perforation in obstetric PDA].

作者信息

Flender H J, Knipprath R, Opitz A

机构信息

Klinik für Anästhesiologie und operative Intensivmedizin, Krankenanstalten Gilead, Bielefeld.

出版信息

Anaesthesist. 1994 Jun;43(6):355-8. doi: 10.1007/s001010050067.

Abstract

The frequency of postspinal headaches after accidental puncture of the subarachnoid space with 16-18 G Tuohy needles is reported at 59-85%. A case of postspinal headache syndrome persisting over a period of 6 weeks following epidural anaesthesia during labour is described. The treatment is discussed. CASE REPORT. A 30-year-old woman had severe postspinal headache for 6 weeks after epidural anaesthesia during labour. Conservative therapy for 3 days and 4 days of bedrest followed by crystalloid infusions during a 3-week hospital stay and a subsequent 3-week period of bedrest at home did not lead to lasting pain relief. Intracranial haematoma and other abnormal processes were excluded by CCT. A pathologic EEG was not confirmed by cranial MRT. A lumbar epidural blood patch of 15 ml of autologous blood was performed at L3/4. The patient stayed in bed for 12 h. After 3 h free of pain the patient complained of recurring headache. After a further 48 h of bedrest she had recovered. Because of lumbar pain 4 days after the epidural blood patch a MRT was performed, which showed the blood at L4 to S3 in the epidural space. DISCUSSION. The diagnosis of a cerebrospinal fluid leakage was based on the history and the main symptom of postspinal headache: the pain onset in the supine position. Such possible treatments as diminishing subarachnoidal pressure by bedrest, increasing cerebrospinal fluid production by infusions, increasing epidural pressure by epidural infusions and closing the cerebrospinal fluid leakage by epidural blood patch are discussed. The average success rate with the epidural blood patch is 93%. Volumes ranging from 5 to 20 ml are discussed for the autologous blood. We chose 15 ml of blood, to take account of the possibility that blood might settle in the wide sacral space. We were able to document the position of the blood patch as L4 to S3 on MR tomography (the injection site was L3/4). Most patients are free of headache 1 h after epidural blood patch. Our patient had to be confined to bed for another 48 h because of recurring headache. The blood patch alone was not immediately sufficient to prevent all further cerebrospinal fluid leakage. Probably more than one subarachnoidal puncture had been made during the difficult epidural anaesthetic procedure. On the other hand, the leak was probably only diminished because of the blood patch descending down to the wide sacral space. The combination of the large-volume blood patch, which diminished the leakage, and conservative treatment, which narrowed the transdural pressure difference, was successful: the 6-week postspinal headache was cured. CONCLUSION. Prolonged postspinal headache should be treated by epidural blood patch. The use of over 10 ml cannot be generally recommended, although in this case most of the blood patch of 15 ml was localized caudally. Careful monitoring for side effects is necessary with blood volumes larger than 10 ml. If there is no immediate relief, conservative therapy with 24-48 h of bedrest is recommended. If the headache persists a second blood patch should be performed, with the volume and the probable caudal spreading of the first taken into account.

摘要

据报道,使用16 - 18G的 Tuohy 针意外刺破蛛网膜下腔后发生脊柱穿刺后头痛的频率为59% - 85%。本文描述了1例分娩期间硬膜外麻醉后持续6周的脊柱穿刺后头痛综合征病例,并对其治疗方法进行了讨论。病例报告:一名30岁女性在分娩期间硬膜外麻醉后出现严重的脊柱穿刺后头痛,持续6周。在为期3周的住院期间,进行了3天的保守治疗和4天的卧床休息,随后进行晶体液输注,并在随后的3周居家期间继续卧床休息,但未能实现持久的疼痛缓解。通过计算机断层扫描(CCT)排除了颅内血肿和其他异常情况。头颅磁共振成像(MRT)未证实存在病理性脑电图。在L3/4处进行了15ml自体血的腰段硬膜外血贴。患者卧床12小时。在无痛3小时后,患者又出现头痛。在进一步卧床休息48小时后,患者康复。由于硬膜外血贴后4天出现腰痛,进行了MRT检查,结果显示硬膜外间隙L4至S3有血液。讨论:脑脊液漏的诊断基于病史和脊柱穿刺后头痛的主要症状:仰卧位时疼痛发作。文中讨论了多种可能的治疗方法,包括通过卧床休息降低蛛网膜下腔压力、通过输液增加脑脊液生成、通过硬膜外输注增加硬膜外压力以及通过硬膜外血贴封闭脑脊液漏。硬膜外血贴的平均成功率为93%。文中讨论了自体血用量在5至20ml之间的情况。我们选择15ml血液,考虑到血液可能在宽阔的骶管间隙沉积的可能性。我们能够在磁共振断层扫描上记录血贴位置为L4至S3(注射部位为L3/4)。大多数患者在硬膜外血贴后1小时内头痛消失。我们的患者由于头痛复发,不得不又卧床48小时。仅血贴本身不足以立即阻止所有进一步的脑脊液漏。在困难的硬膜外麻醉过程中,可能进行了不止一次蛛网膜下腔穿刺。另一方面,漏液可能只是因为血贴向下沉积到宽阔的骶管间隙而减少。大容量血贴减少漏液与保守治疗缩小硬膜内外压力差相结合取得了成功:6周的脊柱穿刺后头痛得以治愈。结论:持续性脊柱穿刺后头痛应采用硬膜外血贴治疗。虽然在本病例中15ml血贴大部分位于尾侧,但一般不建议使用超过10ml的血量。对于血量大于10ml的情况,必须仔细监测副作用。如果没有立即缓解,建议进行24 - 48小时卧床的保守治疗。如果头痛持续,应进行第二次血贴,并考虑第一次血贴的用量和可能的尾侧扩散情况。

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