Reish O, Nachum E, Naor N, Ghoshen J, Merlob P
Department of Neonatology, Beilinson Medical Center, Petah Tiqva, Israel.
Am J Perinatol. 1994 May;11(3):192-3. doi: 10.1055/s-2008-1040743.
A full-term male, healthy newborn infant suddenly developed melena and rectal fresh blood oozing at age of 4 days. He is the second patient described in the literature presenting a spontaneous gastrointestinal bleeding in the neonatal period as the first clinical manifestation of hemophilia B. The early appearance and severity of the hemorrhage, its short duration, and good response to Factor IX (inefficiency of vitamin K) was the characteristics of the affected neonate. Whenever a newborn presents early spontaneous gastrointestinal bleeding, hemophilia B should be considered a possible etiology and blood coagulation studies should be performed accordingly.
一名足月健康男婴在出生4天时突然出现黑便和直肠新鲜血液渗出。他是文献中描述的第二例以新生儿期自发性胃肠道出血为乙型血友病首发临床表现的患者。出血的早期出现、严重程度、持续时间短以及对凝血因子IX的良好反应（维生素K无效）是该患病新生儿的特征。每当新生儿出现早期自发性胃肠道出血时，应考虑乙型血友病可能是病因，并应相应地进行凝血研究。
