Barrington K J, Fox M
Department of Pediatrics, University of Alberta, Edmonton, Canada.
Am J Perinatol. 1994 May;11(3):220-2. doi: 10.1055/s-2008-1040750.
Fifty-two consecutive infants who received intravenous indomethacin, 0.2 mg/kg, were reviewed to determine factors associated with the occurrence of oliguria. Serum creatinine and concentration prior to indomethacin did not predict the occurrence of oliguria. A mean urine output of less than 4.5 mL/kg/hr prior to the administration of indomethacin was the only factor that we determined to be associated with a significant risk of oliguria. Two infants developed symptomatic oliguria and both had a pre-indomethacin urine output less than 1.5 mL/kg/hr.
对连续52例接受0.2mg/kg静脉注射吲哚美辛的婴儿进行了回顾性研究，以确定与少尿发生相关的因素。吲哚美辛治疗前的血清肌酐和浓度不能预测少尿的发生。我们确定，吲哚美辛给药前平均尿量小于4.5mL/kg/hr是与少尿显著风险相关的唯一因素。两名婴儿出现了症状性少尿，且吲哚美辛治疗前的尿量均小于1.5mL/kg/hr。
