[适应周期性低氧可降低阻力动脉的血管收缩反应并增强其血管舒张反应]
[Adaptation to periodic hypoxia decreases vasoconstrictor and increases vasodilator responses of resistant arteries].
作者信息
Mashina S Iu, Meerson F Z
出版信息
Biull Eksp Biol Med. 1993 Apr;115(4):345-7.
PMID:8049384
Abstract
Adaptation to intermittent hypoxia resulted in reduced vasoconstrictor responses of rat tail artery elicited by sympathetic nerve stimulation due to desensitization of alpha- and activation beta 2-adrenoceptors. Endothelium-dependent relaxation was enhanced under the impact of adaptation to intermittent hypoxia. These shifts may play a part in antihypertensive effect of adaptation to hypoxia which has been proved earlier.
摘要
对间歇性低氧的适应导致大鼠尾动脉交感神经刺激引发的血管收缩反应降低，这是由于α - 肾上腺素能受体脱敏和β2 - 肾上腺素能受体激活所致。在对间歇性低氧适应的影响下，内皮依赖性舒张增强。这些变化可能在先前已被证实的低氧适应的降压作用中发挥作用。
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