Luk'ianova L D, Atabaeva R E, Shepeleva S Iu
Biull Eksp Biol Med. 1993 Apr;115(4):366-8.
Antihypoxic effect of a succinate-containing derivative of hydroxypyridine = --mexidol and its analog--emoxipin on contractile function and energy exchange of rats' myocard was investigated. It was shown reliably that mexidole have more expressed protective properties in myocardium of low-resistant (but not high-resistant) rats. In case of antihypoxant emoxipin prohypoxic properties prevail. It have been proposed that antihypoxic activity of mexidol was linked with presence of succinate in composition of the substance, which can be oxidated in this conditions.
研究了含琥珀酸盐的羟基吡啶衍生物——美西律及其类似物艾莫昔芬对大鼠心肌收缩功能和能量代谢的抗缺氧作用。可靠地表明，美西律在低抗（而非高抗）大鼠心肌中具有更明显的保护特性。在抗缺氧剂艾莫昔芬的情况下，促缺氧特性占主导。有人提出，美西律的抗缺氧活性与该物质成分中琥珀酸盐的存在有关，琥珀酸盐在这种情况下可被氧化。
