Baumann P, Skaer H
Department of Zoology, University of Cambridge, UK.
Dev Suppl. 1993:65-75.
Defects in the locus Egfr, encoding the Drosophila EGF receptor homologue (DER), affect the development of the Malpighian tubules. They form as much shorter structures than in wild-type embryos, containing a reduced number of cells. The severity of this phenotype in seven alleles that we have analysed correlates with other embryonic defects caused by Egfr mutations. Interestingly the two pairs of tubules are affected with different severity, with a greater reduction in cell number in the posterior pair than in the anterior. Temperature shift experiments indicate a role for this receptor in the regulation of tubule cell division. We also suggest that an additional role for DER in the allocation of cells to the tubule primordia is possible.
编码果蝇表皮生长因子受体同源物（DER）的Egfr基因座的缺陷会影响马氏管的发育。它们形成的结构比野生型胚胎中的要短得多，所含细胞数量也减少。我们分析的七个等位基因中这种表型的严重程度与Egfr突变引起的其他胚胎缺陷相关。有趣的是，两对小管受到的影响程度不同，后一对小管中的细胞数量减少幅度比前一对更大。温度转换实验表明该受体在小管细胞分裂的调节中起作用。我们还认为DER在将细胞分配到小管原基中可能还有额外作用。
