Penning L C, Dubbelman T M
Department of Medical Biochemistry, Sylvius Laboratory, Leiden, The Netherlands.
Anticancer Drugs. 1994 Apr;5(2):139-46. doi: 10.1097/00001813-199404000-00003.
Photodynamic therapy of cancer is based on the photosensitizing ability of dyes which, after administration, are present in a somewhat higher concentration in tumors than in surrounding normal tissue. After light activation of the sensitizer, singlet oxygen and probably oxygen free radicals are formed and consequently all kinds of cellular components are affected. This review focuses on cellular and biochemical aspects of photodynamic therapy. Both damage to different cellular targets and cellular responses after photodynamic treatment are discussed.
癌症的光动力疗法基于染料的光敏化能力，染料给药后在肿瘤中的浓度略高于周围正常组织。敏化剂经光激活后，会形成单线态氧以及可能的氧自由基，从而影响各种细胞成分。本综述聚焦于光动力疗法的细胞和生化方面。讨论了光动力治疗后对不同细胞靶点的损伤以及细胞反应。
