半桥粒：自身免疫性大疱性疾病的一个靶点。

The hemidesmosome: a target in auto-immune bullous disease.

作者信息

Eady R A

机构信息

St. John's Institute of Dermatology, United Medical School, University of London, UK.

出版信息

Dermatology. 1994;189 Suppl 1:38-41. doi: 10.1159/000246926.

DOI:10.1159/000246926

PMID:8049561

Abstract

Hemidesmosomes are subcellular structures that are involved in the attachment of a variety of epithelial cells, including basal epidermal keratinocytes, to the extracellular matrix. Like desmosomes, they provide a link between the intracytoplasmic keratin intermediate filaments and the plasma membrane. Major hemidesmosome plaque components include the bullous pemphigoid antigens of 230 and 180 kD and the alpha 6 beta 4-integrin. These transmembrane proteins may associate extracellularly with anchoring filament components including the 19-DEJ-1 proteoglycan and the polymeric proteins nicein/kalinin and epiligrin. Several of these hemidesmosome-related components have been implicated as targets for circulating auto-antibodies in immuno bullous disorders.

摘要

半桥粒是一种亚细胞结构，参与多种上皮细胞（包括基底表皮角质形成细胞）与细胞外基质的附着。与桥粒一样，它们在细胞质内的角蛋白中间丝和质膜之间提供连接。主要的半桥粒斑块成分包括230和180kD的大疱性类天疱疮抗原以及α6β4整合素。这些跨膜蛋白可能在细胞外与包括19-DEJ-1蛋白聚糖以及聚合蛋白nicein/kalinin和表皮整联配体蛋白在内的锚定丝成分结合。这些与半桥粒相关的成分中有几种已被认为是免疫性大疱性疾病中循环自身抗体的靶标。