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大疱性类天疱疮中特定整合素和选择素的表达

Expression of selected integrins and selectins in bullous pemphigoid.

作者信息

Zebrowska Agnieszka, Sysa-Jedrzejowska Anna, Wagrowska-Danilewicz Małgorzata, Joss-Wichman Ewa, Erkiert-Polguj Anna, Waszczykowska Elzbieta

机构信息

Department of Dermatology and Venereology, Medical University of Lodz, 94-017 Lodz, Poland.

出版信息

Mediators Inflamm. 2007;2007:31051. doi: 10.1155/2007/31051. Epub 2007 Apr 2.

DOI:10.1155/2007/31051
PMID:17515951
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1868076/
Abstract

Blister development in bullous pemphigoid (BP) results from destruction of hemidesmosomes and basement membrane components within the dermoepidermal junction by autoantibodies. Adhesion molecules can take part in pathogenesis of this disease. The aim of the study was to determine the localization and expression of L- and E-selectins and beta1, beta3, and beta4 integrins by immunohistochemistry in skin lesions of 21 patients with BP, compared with 10 healthy subjects. Expression of L and E selectins and beta1, beta3 integrins was detected mainly in basal keratinocytes and in inflammatory infiltrates in the dermis, expression of beta4 integrin was irregular and was detected mainly in dermal part of the blister, while in the control group only weak and single expression of the examined molecules was detected in basal keratinocytes and endothelium cells. The obtained results reveal the important role of selected selectins and integrins in development of skin lesions in BP.

摘要

大疱性类天疱疮（BP）中的水疱形成是由自身抗体破坏真皮表皮连接处的半桥粒和基底膜成分所致。黏附分子可参与该疾病的发病机制。本研究的目的是通过免疫组织化学法确定21例BP患者皮肤病变中L-选择素、E-选择素以及β1、β3和β4整合素的定位和表达，并与10名健康受试者进行比较。L-选择素、E-选择素以及β1、β3整合素的表达主要在基底角质形成细胞和真皮中的炎性浸润中检测到，β4整合素的表达不规则，主要在水疱的真皮部分检测到，而在对照组中，仅在基底角质形成细胞和内皮细胞中检测到所检测分子的微弱和单一表达。所得结果揭示了所选选择素和整合素在BP皮肤病变发展中的重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/1868076/21f95679623a/MI2007-31051.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/1868076/295c87776d89/MI2007-31051.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/1868076/d48f65525328/MI2007-31051.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/1868076/7578b1d7a81e/MI2007-31051.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/1868076/7a464d20e53f/MI2007-31051.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/1868076/cfc30c4ce8a2/MI2007-31051.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/1868076/431d737e28a4/MI2007-31051.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/1868076/21f95679623a/MI2007-31051.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/1868076/295c87776d89/MI2007-31051.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/1868076/d48f65525328/MI2007-31051.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/1868076/7578b1d7a81e/MI2007-31051.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/1868076/7a464d20e53f/MI2007-31051.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/1868076/cfc30c4ce8a2/MI2007-31051.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/1868076/431d737e28a4/MI2007-31051.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/1868076/21f95679623a/MI2007-31051.007.jpg

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本文引用的文献

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Identification of an epitope within human integrin alpha 6 subunit for the binding of autoantibody and its role in basement membrane separation in oral pemphigoid.鉴定人整合素α6亚基内与自身抗体结合的表位及其在口腔类天疱疮基底膜分离中的作用。
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Differential roles for beta2 integrins in experimental autoimmune bullous pemphigoid.β2整合素在实验性自身免疫性大疱性类天疱疮中的不同作用
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Integrins: structure and signaling.
整合素：结构与信号传导
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New insights into the structural basis of integrin activation.整合素激活结构基础的新见解。
Blood. 2003 Aug 15;102(4):1155-9. doi: 10.1182/blood-2003-01-0334. Epub 2003 Apr 24.
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Alpha4 integrins as therapeutic targets in autoimmune disease.α4整合素作为自身免疫性疾病的治疗靶点。
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Natalizumab for active Crohn's disease.那他珠单抗用于活动性克罗恩病
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Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.对BP180、BP230、网蛋白和整合素α6β4之间相互作用的分析，这些相互作用对半桥粒组装至关重要。
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