Roth J A
Department of Thoracic Surgery, University of Texas M.D. Anderson Cancer Center, Houston.
Chest Surg Clin N Am. 1994 May;4(2):205-16.
An analysis of the molecular events underlying the development of esophageal cancer may yield new strategies for diagnosis, prevention, and therapy. Oncogenes and tumor suppressor genes have been implicated in the development of esophageal cancer. Tumor suppressor gene mutations are present in Barrett's epithelium, the premalignant lesion for adenocarcinoma. Early genetic changes may predict the development of invasive cancer. Recent data suggest that reversal of single gene abnormalities can reduce the tumorigenic potential of cancer cells.
对食管癌发生发展背后分子事件的分析可能会产生诊断、预防和治疗的新策略。癌基因和肿瘤抑制基因与食管癌的发生发展有关。肿瘤抑制基因突变存在于腺癌的癌前病变巴雷特食管上皮中。早期基因变化可能预测浸润性癌的发展。最近的数据表明，单基因异常的逆转可降低癌细胞的致瘤潜力。
