从人血清中分离出两种新的胰蛋白酶抑制组分。
Separation of two new trypsin-inhibiting fractions from human serum.
作者信息
Nowak S, Bieth J, Miesch F
出版信息
Enzyme. 1975;20(2):71-9. doi: 10.1159/000458922.
PMID:805046
Abstract
Trace amounts of two unknown trypsin-inhibiting fractions have been separated from pooled human serum by DEAE-Sephadex chromatography. They are immunologically different from alpha1-antitrypsin, alpha2-macroglobulin or inter-alpha-trypsin inhibitor and they form two well separated peaks after rechromatography on DEAE-Sephadex column. Both of these fractions also inhibit chymotrypsin but not elastase. Their relation to other trypsin inhibitors of human serum is discussed.
摘要
通过二乙氨基乙基葡聚糖（DEAE - Sephadex）柱层析法，从混合人血清中分离出了痕量的两种未知的胰蛋白酶抑制组分。它们在免疫方面与α1 - 抗胰蛋白酶、α2 - 巨球蛋白或α间胰蛋白酶抑制剂不同，并且在DEAE - Sephadex柱上再次层析后形成了两个分离良好的峰。这两种组分均能抑制胰凝乳蛋白酶，但不抑制弹性蛋白酶。文中讨论了它们与人血清中其他胰蛋白酶抑制剂的关系。
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