甘氨酸对非氨酯抗惊厥作用的选择性拮抗

Selective antagonism of the anticonvulsant effects of felbamate by glycine.

作者信息

Coffin V, Cohen-Williams M, Barnett A

机构信息

Schering-Plough Research Institute, Kenilworth, NJ 07033-0539.

出版信息

Eur J Pharmacol. 1994 Apr 21;256(2):R9-10. doi: 10.1016/0014-2999(94)90253-4.

DOI:10.1016/0014-2999(94)90253-4

PMID:8050461

Abstract

Glycine blocked the anticonvulsant effects of felbamate on electroshock- and NMDA-induced seizures in mice. In contrast to its effects on felbamate, glycine either potentiated or had no effect on the anticonvulsant actions of phenytoin, valproate, carbamazepine and phenobarbital on electroshock seizures in mice. The data support that the glycine-felbamate blockade is a specific interaction. Felbamate is likely to be the first clinically available anticonvulsant drug that acts through this unique mechanism.

摘要

甘氨酸可阻断非氨酯对小鼠电休克和N-甲基-D-天冬氨酸（NMDA）诱导癫痫发作的抗惊厥作用。与它对非氨酯的作用相反，甘氨酸对苯妥英、丙戊酸、卡马西平和苯巴比妥对小鼠电休克癫痫发作的抗惊厥作用，要么有增强作用，要么没有影响。这些数据支持甘氨酸-非氨酯阻断是一种特异性相互作用。非氨酯可能是首个通过这种独特机制起作用的临床可用抗惊厥药物。