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应用外部磁场逆转帕金森病的视觉构建障碍:5例报告

Reversal of a visuoconstructional deficit in Parkinson's disease by application of external magnetic fields: a report of five cases.

作者信息

Sandyk R

机构信息

NeuroCommunication Research Laboratories, Danbury, CT 06811.

出版信息

Int J Neurosci. 1994 Apr;75(3-4):213-28. doi: 10.3109/00207459408986305.

DOI:10.3109/00207459408986305
PMID:8050863
Abstract

Visuoperceptive and visuomotor deficits are among the most frequently encountered abnormalities in neuropsychological testing of patients with Parkinson's disease, being present in up to 90% of cases. Clinically, the presence of visuoperceptive and visuomotor impairment may not be noted by Parkinsonian patients but may contribute to various functional disabilities including difficulties operating a vehicle, ambulating, and dressing. The present communication concerns five medicated Parkinsonian patients who responded to extracranial treatment with magnetic fields in the picotesia range intensity with improvement in motor, behavioral, and autonomic functions as well as visuoconstructional tasks as demonstrated on the Bicycle Drawing test. Specifically, prior to treatment with magnetic fields these patients failed to draw the spokes in the wheels of a bicycle that extended completely to the periphery of the rim. I considered this observation to reflect a specific visuoconstructional deficit inherent to the Parkinsonian disease process. This visuoconstructional impairment was reversed, however, by external applications of magnetic fields. The report supports prior observations demonstrating that picotesla range intensity magnetic fields may bring about reversal of specific cognitive deficits in Parkinsonian patients.

摘要

视觉感知和视觉运动缺陷是帕金森病患者神经心理学测试中最常遇到的异常情况之一,高达90%的病例中存在此类情况。临床上,帕金森病患者可能未注意到视觉感知和视觉运动障碍的存在,但这可能导致各种功能残疾,包括操作车辆、行走和穿衣困难。本报告涉及五名接受药物治疗的帕金森病患者,他们接受了皮特斯拉范围内强度的颅外磁场治疗,结果显示运动、行为和自主功能以及视觉构建任务(如在自行车绘图测试中所示)均有改善。具体而言,在接受磁场治疗之前,这些患者未能画出完全延伸到轮辋边缘的自行车车轮辐条。我认为这一观察结果反映了帕金森病病程中固有的一种特定视觉构建缺陷。然而,通过外部施加磁场,这种视觉构建障碍得到了逆转。该报告支持了先前的观察结果,即皮特斯拉范围内强度的磁场可能会逆转帕金森病患者的特定认知缺陷。

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