Scannell J P, Pruess D, Blount J F, Ax H A, Kellett M, Weiss F, Demny T C, Williams T H, Stempel A
J Antibiot (Tokyo). 1975 Jan;28(1):1-6. doi: 10.7164/antibiotics.28.1.
(S)-Alanyl-3-[alpha-(S)-chloro-3-(S)-hydroxy-2-oxo-3-azetidinylmethyl]-(S)-alanine was isolated from a fermentation broth of an unidentified Streptomyces species 372 A. The structure was determined by single crystal X-ray diffraction analysis. The substance inhibits the growth of several strains of gram-positive and gram-negative bacteria in a chemically defined medium but growth inhibition is relieved by addition of L-glutamine to the medium.
（S）-丙氨酰-3-[α-（S）-氯-3-（S）-羟基-2-氧代-3-氮杂环丁烷基甲基] -（S）-丙氨酸是从一株未鉴定的链霉菌属372 A的发酵液中分离得到的。其结构通过单晶X射线衍射分析确定。该物质在化学成分明确的培养基中能抑制几种革兰氏阳性菌和革兰氏阴性菌的生长，但向培养基中添加L-谷氨酰胺可缓解生长抑制。
