Azizi F, Vagenakis A G, Braverman L E
Johns Hopkins Med J. 1975 Jan;136(1):11-4.
The effect of a single large intramuscular injections of TRH (2 mg) on the thyroid 131I uptake in normal man was assessed at varying intervals following the administration of TRH. When the 131I was given simultaneously with TRH, the 3- and 5-hour 131I uptake decreased. When the 131I was administered 8 hours after TRH, the thyroid 131I increased significantly. This response in uptake is similar to that observed in the rat following TSH stimulation. The present study defines the time course of the thyroid 131I uptake response to endogenous TSH stimulation.
单次大剂量肌肉注射促甲状腺激素释放激素（TRH，2毫克）对正常男性甲状腺131碘摄取的影响，在注射TRH后的不同时间间隔进行了评估。当131碘与TRH同时给予时，3小时和5小时的131碘摄取量下降。当在TRH注射8小时后给予131碘时，甲状腺131碘摄取量显著增加。这种摄取反应与在大鼠中促甲状腺激素（TSH）刺激后观察到的反应相似。本研究确定了甲状腺对内源性TSH刺激的131碘摄取反应的时间进程。
