Spessotto P, Bulla R, Mittenzwei H, Dri P
Institute of General Pathology, University of Trieste, Italy.
Arzneimittelforschung. 1994 Jun;44(6):770-3.
The effect of Factor AF2 (AF2), a standardized fraction of peptides with a molecular weight of < 10,000 Dalton obtained from livers and spleens of newborn lambs, on the differentiation of human monocyte-derived macrophages was studied, in view of the central role played by these cells in inflammation and tumor cytotoxicity. The results show that the drug 1. increases the cell density of cultures, 2. favours the morphologic differentiation of monocytes into macrophages, and 3. increases the macrophages phagocytic capacity. The first two effects are observed when monocytes are cultured in 1% serum but not in 10% serum while the enhancement of phagocytic activity is detected at both serum concentrations.
鉴于人类单核细胞衍生的巨噬细胞在炎症和肿瘤细胞毒性中发挥的核心作用，研究了从新生羔羊肝脏和脾脏中获得的分子量小于10,000道尔顿的标准化肽组分AF2对这些巨噬细胞分化的影响。结果表明，该药物1. 增加培养物的细胞密度，2. 促进单核细胞向巨噬细胞的形态分化，3. 提高巨噬细胞的吞噬能力。前两种效应在单核细胞于1%血清中培养时可观察到，而在10%血清中培养时未观察到，而在两种血清浓度下均检测到吞噬活性增强。
