Asamura H, Tsuchiya R, Goya T, Kondo H, Naruke T, Saijo N, Suemasu K
Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan.
Surg Today. 1994;24(2):137-41. doi: 10.1007/BF02473395.
Twenty-five patients with a malignant germ cell tumor of the mediastinum were treated at the National Cancer Center Hospital, Tokyo. Three patients had pure seminomas while 22 had a nonseminomatous histology. The treatment modalities consisted of surgery alone in 7 patients, surgery with chemotherapy and/or radiation in 14, and chemotherapy and/or radiation without surgery in 4. Cisplatin-based chemotherapy was administered in nine patients, one of whom successfully underwent high-dose chemotherapy with autologous bone marrow transplantation after resection of the tumor. A complete response was achieved in only five patients. The overall survival rate at 5 years was 33.5% and the median survival time was 51 weeks. Eight patients (32%), all of whom underwent surgery either with or without chemotherapy and/or radiation, were free of disease with a mean follow-up period of 439 weeks (72-1,120 weeks). The median survival times for 14 patients undergoing combined modality treatment, 7 patients undergoing surgery alone, and 4 patients undergoing chemotherapy and/or radiation were 83, 16, and 18 weeks, respectively.
东京国立癌症中心医院对25例纵隔恶性生殖细胞肿瘤患者进行了治疗。其中3例为纯精原细胞瘤，22例为非精原细胞瘤组织学类型。治疗方式包括：7例仅接受手术治疗；14例接受手术联合化疗和/或放疗；4例接受化疗和/或放疗但未手术。9例患者接受了以顺铂为基础的化疗，其中1例在肿瘤切除后成功接受了大剂量化疗及自体骨髓移植。仅5例患者达到完全缓解。5年总生存率为33.5%，中位生存时间为51周。8例患者（32%）无疾病生存，这些患者均接受了手术，其中部分联合或未联合化疗和/或放疗，平均随访期为439周（72 - 1120周）。14例接受综合治疗、7例仅接受手术治疗、4例接受化疗和/或放疗的患者的中位生存时间分别为83周、16周和18周。
