Tsuda H, Mukai K, Fukutomi T, Hirohashi S
Pathology Division, National Cancer Center Research Institute and Hospital, Tokyo, Japan.
Pathol Int. 1994 Jun;44(6):475-9. doi: 10.1111/j.1440-1827.1994.tb01713.x.
A case of breast tumor is described, which consisted of dense and uniform proliferation of ducts and lobules composed of both epithelial and myoepithelial cells and in which multiple foci of adenocarcinoma were observed. The tumor surrounding the carcinoma foci was identified as 'adenomyoepithelial adenosis'. Adenomyoepithelial adenosis was not monoclonal by clonal analysis, but revealed a relatively high labeling index for proliferating cell nuclear antigen by immunohistochemistry. Although it was still undetermined whether adenomyoepithelial adenosis is a non-clonal nonneoplastic lesion or a biclonal neoplastic one, the lesion was shown to reveal high proliferative activity in both glandular epithelial and myoepithelial cells and was considered to be prone to progress to obvious carcinoma.
本文描述了一例乳腺肿瘤，其由导管和小叶的致密且均匀增生组成，导管和小叶由上皮细胞和肌上皮细胞构成，并观察到多个腺癌病灶。癌灶周围的肿瘤被鉴定为“腺肌上皮腺病”。通过克隆分析，腺肌上皮腺病并非单克隆性，但免疫组化显示增殖细胞核抗原的标记指数相对较高。尽管腺肌上皮腺病是一种非克隆性非肿瘤性病变还是双克隆性肿瘤性病变仍未确定，但该病变在腺上皮细胞和肌上皮细胞中均显示出高增殖活性，且被认为易于进展为明显的癌。
