Wallace R B
Am J Cardiol. 1975 Jun;35(6):866-71. doi: 10.1016/0002-9149(75)90123-x.
The search for an ideal replacement for diseased intracardiac valves has resulted in the use of many tissue valves, including homografts, heterografts and valves of autologous and heterologous fascia lata and of pericardium. Operative mortality in experienced hands has been comparable to that of other operations using prosthetic valves. Sterilization and preservation techniques probably render the graft nonviable in all instances. Although early function has been satisfactory, late deterioration of leaflet tissue has led to valve failure in a high percentage of cases. At present, glutaraldehyde-prepared heterografts and fresh antibiotic-sterilized homografts appear to have the longest durability of the various tissue grafts used for valve replacement. The primary advantage of tissue valves has been the essential elimination of thromboembolic complications, and the primary problems have been infectious endocarditis and late graft deterioration.
寻找理想的病变心内瓣膜替代物导致了多种组织瓣膜的应用，包括同种异体移植物、异种移植物以及自体和异体阔筋膜与心包瓣膜。在经验丰富的医生手中，手术死亡率与使用人工瓣膜的其他手术相当。灭菌和保存技术可能在所有情况下都会使移植物失去活力。尽管早期功能令人满意，但瓣叶组织的晚期退化导致了高比例病例的瓣膜失效。目前，戊二醛处理的异种移植物和新鲜抗生素灭菌的同种异体移植物似乎在用于瓣膜置换的各种组织移植物中具有最长的耐久性。组织瓣膜的主要优点是基本消除了血栓栓塞并发症，主要问题是感染性心内膜炎和移植物晚期退化。
