Whishaw I Q, Rod M R, Auer R N
Department of Psychology, University of Lethbridge, Alberta, Canada.
Brain Res Bull. 1994;34(3):283-9. doi: 10.1016/0361-9230(94)90065-5.
Ischemia causes neuronal necrosis in the septal half of the CA1 sector of the hippocampus in rats and produces deficits in spatial and other tasks, but the impairments are not severe. CA1-damaged rats may perform at control levels on some tests and may overlap the performance of control animals on other tests. The present study examined the performance of CA1-damaged rats on a range of tests known to be sensitive to hippocampal damage and evaluated the size of the deficit using a composite test-battery score. The rats with CA1 damage were impaired on learning set, matching to place, and latent-learning spatial navigation in a swimming pool, delayed alteration, and pattern alternation on dry land, but not on amphetamine-induced locomotion or on negative patterning. The CA1-damaged rats' impairments were mild, characterized by behavioral strategies similar to those of control rats, and their tests scores overlapped those of control rats. Nevertheless, a composite profile derived from the measures obtained from the different tests revealed a large overall impairment. The results confirm that rats with partial damage to CA1 display impairments, especially on tests that demand working memory, and suggest that the test-battery approach can be used to enhance group differences.
缺血会导致大鼠海马体CA1区中隔半区的神经元坏死，并在空间及其他任务中产生缺陷，但这些损伤并不严重。CA1区受损的大鼠在某些测试中可能表现出与对照组相当的水平，而在其他测试中其表现可能与对照动物重叠。本研究检测了CA1区受损大鼠在一系列已知对海马体损伤敏感的测试中的表现，并使用综合测试组分数评估缺陷的程度。CA1区受损的大鼠在学习集、地点匹配、游泳池中的潜伏学习空间导航、延迟交替以及陆地上的模式交替等测试中表现受损，但在苯丙胺诱导的运动或负性模式测试中未受损。CA1区受损大鼠的损伤程度较轻，其行为策略与对照大鼠相似，测试分数也与对照大鼠重叠。然而，从不同测试获得的测量结果得出的综合概况显示出总体上的严重损伤。结果证实，CA1区部分受损的大鼠存在损伤，尤其是在需要工作记忆的测试中，并表明综合测试组方法可用于增强组间差异。
