对五例塞扎里综合征患者的细胞遗传学研究。

Cytogenetic studies in five patients with Sézary syndrome.

作者信息

Solé F, Woessner S, Vallespi T, Pérez Losada A, Florensa L, Irriguible D, Vila J, Sans-Sabrafen J

机构信息

Laboratori de Citologia Hematològica, Hospital Central L'Aliança, Barcelona, Spain.

出版信息

Cancer Genet Cytogenet. 1994 Jul 15;75(2):130-2. doi: 10.1016/0165-4608(94)90164-3.

DOI:10.1016/0165-4608(94)90164-3

PMID:8055476

Abstract

A cytogenetic study was performed in five patients with Sézary syndrome. Metaphases were obtained from a phytohemagglutinin-stimulated lymphocyte culture. The five patients showed abnormal karyotypes. The chromosomes preferentially involved in numerical aberrations were chromosomes 10 (monosomy) and 13 (monosomy); involved in structural changes were chromosomes 1, 2, 4, 6, and 14. In our series, all patients showed progression of the disease.

摘要

对5例 Sézary 综合征患者进行了细胞遗传学研究。通过植物血凝素刺激的淋巴细胞培养获得中期分裂相。这5例患者均显示核型异常。在数目畸变中优先受累的染色体是10号染色体（单体）和13号染色体（单体）；在结构改变中受累的染色体是1、2、4、6和14号染色体。在我们的病例系列中，所有患者均出现疾病进展。