Arch Dis Child. 1975 Feb;50(2):90-102. doi: 10.1136/adc.50.2.90.
A screening survey for asymptomatic bacteriuria (ASB) in 13464 schoolgirls aged 4 to 18 years in Newcastle upon Tyne showed an overall prevalence of 1.9%. In girls 4 to 6 years it was 1.4%, in girls aged 7 to 11 years it was 2.5%, in girls aged 12 to 18 years it was 1.6%, a statistically significant rise and fall. Renal scarring was found in 39 (15%) of 254 girls with ASB. Neither the prevalence nor the severity of renal scarring increased with age. There was no association between ASB and social class. Of the 254 girls with ASB, 24% had no symptoms. Infections with klebsiella were more frequently associated with renal scarring than infections with Esch. coli. The prevalence of ASB in 1595 boys aged 5 to 18 was low, 0.2%. Ureteric reflux was present in 15% of girls without renal scarring and in 46% of those with renal scarring (P less than 0.001). Renal scarring also showed a significant association with duplication, hydroureter, or single saccules in the bladder. The greater the severity of scarring the more frequently was reflux present. This study gave no evidence that asymptomatic bacteriuria leads to progressive renal damage during childhood. It therefore does not support the recommendation for prescriptive screening of schoolchildren, but emphasizes the need for prospective studies of the natural history of ASB.
对泰恩河畔纽卡斯尔13464名4至18岁女学生进行的无症状菌尿（ASB）筛查调查显示，总体患病率为1.9%。4至6岁女童的患病率为1.4%，7至11岁女童为2.5%，12至18岁女童为1.6%，呈统计学上显著的先升后降。在254例ASB女童中，有39例（15%）发现有肾瘢痕形成。肾瘢痕形成的患病率和严重程度均不随年龄增加。ASB与社会阶层之间无关联。在254例ASB女童中，24%没有症状。克雷伯菌感染比大肠杆菌感染更常与肾瘢痕形成相关。1595例5至18岁男童的ASB患病率较低，为0.2%。无肾瘢痕形成的女童中15%存在输尿管反流，有肾瘢痕形成的女童中46%存在输尿管反流（P<0.001）。肾瘢痕形成还与膀胱重复、输尿管积水或单房性囊肿显著相关。瘢痕形成越严重，反流出现的频率越高。这项研究没有证据表明无症状菌尿会在儿童期导致进行性肾损害。因此，它不支持对学童进行规定性筛查的建议，但强调需要对ASB的自然史进行前瞻性研究。
