Nyongo A O
Department of Human Pathology, College of Health Sciences, University of Nairobi, Kenya.
East Afr Med J. 1994 Jan;71(1):32-4.
To evaluate the association between ectopic pregnancy (EP) and smoking, a hospital based case-control study was undertaken. Also studied were other potential risk factors namely: PID, undernutrition, blood group 'O', the use of IUD, prior abnormal pregnancies and prior abdominal surgery. The investigation included 72 cases diagnosed at the University of Health Sciences, Kansas City, Missouri from January 1, 1976 through December 31, 1987 and 72 pair-matched controls selected from live-birth deliveries at the same hospital. Univariable McNemar analyses revealed four strong risk factors: having ever smoked (OR = 2.1, p = 0.04), previous EP (OR = 14.3, p = 0.0001), previous fetal loss (OR = 4, p = 0.04) and previous pelvic and abdominal surgery (OR = 6.3 p = 0.0001). A stepwise logistic regression analysis using parity, eversmoking, underweight and PID was performed. Only PID remained strongly associated with EP after the first step (p = 0.009).
为评估异位妊娠（EP）与吸烟之间的关联，开展了一项基于医院的病例对照研究。还研究了其他潜在风险因素，即盆腔炎（PID）、营养不良、O型血、宫内节育器（IUD）的使用、既往异常妊娠和既往腹部手术。该调查纳入了1976年1月1日至1987年12月31日期间在密苏里州堪萨斯城健康科学大学确诊的72例病例，以及从同一家医院的活产分娩中选取的72例配对对照。单变量McNemar分析揭示了四个强风险因素：曾经吸烟（比值比[OR]=2.1，p=0.04）、既往异位妊娠（OR=14.3，p=0.0001）、既往胎儿丢失（OR=4，p=0.04）和既往盆腔及腹部手术（OR=6.3，p=0.0001）。使用产次、曾经吸烟、体重过轻和盆腔炎进行了逐步逻辑回归分析。第一步之后，仅盆腔炎仍与异位妊娠密切相关（p=0.009）。
