Bednarek-Tupikowska G, Bohdanowicz-Pawlak A, Bolanowski M, Jedrzejak J, Milewicz A
Katedra i Klinika Endokrynologii AM, Wrocławiu.
Endokrynol Pol. 1993;44(2):161-8.
Long-acting bromocriptine (Parlodel LAR) was used for treatment of 25 patients with acromegaly during the period of 3 to 24 months. Even after the first intramuscular injection of 50 milligrams of the drug a decrease in growth hormone (GH) concentration by at least 50% of the initial values was observed in 28% of patients and an improvement in a sense of well-being in 44%. After 6 months of administration of 100 mg of Parlodel LAR at intervals of 28 days a decrease in GH level by at least 50% was observed in a larger percentage of patients (36.8%), and in 10.5% of them there was a fall of GH concentration to below 10 microU/ml. Side effects, like nausea, vomiting and orthostatic hypotony, appeared within several hours after the injection of Parlodel and lasted in most cases up to 24 hours. After consecutive injections of the drug the side effects were of lesser intensity or completely disappeared. The results obtained allow to conclude that Parlodel LAR is an effective drug in some cases of acromegaly. In most patients the therapeutic effect can be seen after the first injection, but in some cases it appears only after several months of treatment.
长效溴隐亭（帕罗西汀长效注射剂）在3至24个月期间用于治疗25例肢端肥大症患者。即使在首次肌肉注射50毫克该药物后，28%的患者生长激素（GH）浓度下降至少初始值的50%，44%的患者幸福感得到改善。在每隔28天注射100毫克帕罗西汀长效注射剂6个月后，更大比例的患者（36.8%）GH水平下降至少50%，其中10.5%的患者GH浓度降至10微国际单位/毫升以下。副作用如恶心、呕吐和体位性低血压在注射帕罗西汀后数小时内出现，大多数情况下持续长达24小时。连续注射该药物后，副作用强度减轻或完全消失。所得结果表明，帕罗西汀长效注射剂在某些肢端肥大症病例中是一种有效药物。大多数患者在首次注射后即可看到治疗效果，但在某些情况下，仅在治疗数月后才会出现。
