Miyaki K, Murakami K, Segami N, Iizuka T
Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Kyoto University, Japan.
J Oral Rehabil. 1994 May;21(3):299-310. doi: 10.1111/j.1365-2842.1994.tb01145.x.
Total discectomy was performed experimentally in the rabbit temporomandibular joint (TMJ). In order to evaluate the injury and repair of the articular cartilage of the mandibular condyle after discectomy, both histologic and immunohistochemical observations were made. Immunohistochemical observation by using bromodeoxyuridine (BrdU) and its monoclonal antibody in vivo labelling method was used. The present study demonstrated that the cartilage on the articular surface of the condyle disappeared at 1 week post-operatively. This defect in the injured articular cartilage was not repaired by the cartilage, but was covered by a fibrous connective tissue at 6 weeks post-operatively, where the condylar recontouring by the adjacent articular cartilage, and flattening and hyperplasia of the condyle were observed. Thus, the cartilaginous repair following discectomy was characterized by the proliferation of the adjacent cartilage to the injured site and osteoblastic formation in the bone marrow at the exposed subchondral bone.
在兔颞下颌关节（TMJ）上进行了全椎间盘切除术实验。为了评估椎间盘切除术后下颌髁突关节软骨的损伤和修复情况，进行了组织学和免疫组织化学观察。采用溴脱氧尿苷（BrdU）及其单克隆抗体体内标记法进行免疫组织化学观察。本研究表明，术后1周髁突关节表面的软骨消失。受损关节软骨的这种缺损未被软骨修复，而是在术后6周被纤维结缔组织覆盖，在该部位观察到相邻关节软骨对髁突进行重塑，以及髁突变平和增生。因此，椎间盘切除术后的软骨修复特征是相邻软骨向损伤部位增殖以及暴露的软骨下骨骨髓中形成成骨细胞。
