Shulman R J, Redel C A, Stathos T H
USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas.
J Pediatr Gastroenterol Nutr. 1994 Apr;18(3):350-4. doi: 10.1097/00005176-199404000-00017.
Although bolus and continuous tube feedings are common, little is known about their effect on the developing small intestine. To compare their effect on small-intestinal growth and differentiation, six pairs of 3-day-old piglet littermates were randomized to receive similar volumes of sow milk replacer, either by bolus (four times daily, group B) or continuous feedings (over 24 h, group C) for 7 days. The piglets were then killed and small-intestinal length, weight, protein mass, and disaccharidase activities were determined. Small-intestinal mucosal weight and ileal protein mass were greater in group B than in group C (p = 0.0024 and 0.019, respectively). No differences were noted between groups in jejunal mucosal protein mass. Ileal maltase activity also was greater in group B than group C (p = 0.02). Although ileal lactase activity in group B was twice that in group C, the differences did not quite reach statistical significance (p = 0.11). No differences between groups were noted in ileal or jejunal sucrase activity. Our study demonstrated that bolus feedings increased mucosal mass, protein mass, and maltase activity to a greater degree than continuous feedings. These results may have clinical significance for infants receiving long-term tube feedings.
尽管推注式和持续管饲法很常见，但对于它们对发育中的小肠的影响却知之甚少。为比较它们对小肠生长和分化的影响，将六对3日龄仔猪同窝仔随机分为两组，分别接受等量的母猪代乳品，一组采用推注法（每日四次，B组），另一组采用持续饲喂法（24小时持续进行，C组），为期7天。然后处死仔猪，测定小肠长度、重量、蛋白质含量和双糖酶活性。B组的小肠黏膜重量和回肠蛋白质含量均高于C组（分别为p = 0.0024和0.019）。空肠黏膜蛋白质含量在两组间无差异。B组的回肠麦芽糖酶活性也高于C组（p = 0.02）。虽然B组的回肠乳糖酶活性是C组的两倍，但差异未达到统计学意义（p = 0.11）。两组的回肠或空肠蔗糖酶活性无差异。我们的研究表明，推注式喂养比持续喂养在更大程度上增加了黏膜质量、蛋白质含量和麦芽糖酶活性。这些结果可能对接受长期管饲的婴儿具有临床意义。
